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As shown in Scheme 7, Heck-type cross-couplings can be performed by suspending a halogenated tetracycline compound (eg, 7-iodo 4-dedimethylamino sancycline, 7A) and an appropriate palladium or other transition metal catalyst (eg, Pd(OAc) 2 and CuI) in an appropriate solvent (eg, degassed acetonitrile).

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• Turn the vial and syringe upside down (see Figure 2). Generalised convulsions after consuming a large amount of ginkgo nuts.

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